Publications & Achievements

A record of our publications, conference presentations, awards, and scientific contributions.

For a fully updated and comprehensive list of Dr. Kobayashi's publications, please visit his official NCBI bibliography:

[ MyNCBI Bibliography ]

2026

Publication

Caloric Restriction Attenuates Oxidative Injury but Fails to Reverse Established Cardiac Remodeling in Atrial Natriuretic Peptide Receptor 1-Deficient Mice

Kobayashi S, Liang Q, et al.

Int J Drug Discov Pharm. 2026

2025

Publication

Repurposing metformin for cardioprotection: mechanisms and therapeutic potential across cardiovascular pathologies

Khinchin J, Rakoubian A, Romano V, Ryan T, Yarbro J, Kobayashi S, et al.

Front Pharmacol. 2026;17:1681783

2024

Publication

Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology

Rakoubian A, Khinchin J, Yarbro J, Kobayashi S, and Liang Q

Front Cardiovasc Med. 2025;12:1638515

Publication

Unraveling the Roles of HIF-1, HO-1, GLUT-1 and GLUT-4 in Myocardial Protection

Chong L, Dushaj N, Rakoubian A, Yarbro J, Kobayashi S, and Liang Q

Int J Drug Discov Pharm. 2024 Sep;3(3):

Publication

Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes

Nakayama Y, Kobayashi S, Masihuddin A, Abdali SA, Seneviratne AMPB, Ishii S, et al.

Circ Res. 2024 Jul 19;135(3):416-433

2023

Publication

Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death

Van J, Hahn Y, Silverstein B, Li C, Cai F, Wei J, et al.

Int J Drug Discov Pharm. 2023 Mar;2(1):37-51

2022

Publication

Lysosomal dysfunction in diabetic cardiomyopathy

Kobayashi S, Hahn Y, Silverstein B, Singh M, Fleitz A, Van J, et al.

Front Aging. 2023;4:1113200

Publication

Stabilizing Cardiac Ryanodine Receptor With Dantrolene Treatment Prevents Binge Alcohol-Enhanced Atrial Fibrillation in Rats

Greco LV, Migirov A, Ojamaa K, Li Y, Huang Y, Kobayashi S, et al.

J Cardiovasc Pharmacol. 2022 Nov 1;80(5):739-745

2020

Publication

Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes

Chen Z, Liang Q, Wu Y, Gao Z, Kobayashi S, Patel J, et al.

Metabolomics. 2020 Oct 16;16(11):115

Publication

Novel Dual-Fluorescent Mitophagy Reporter Reveals a Reduced Mitophagy Flux in Type 1 Diabetic Mouse Heart

Kobayashi S, Patel J, Zhao F, Huang Y, Kobayashi T, and Liang Q

J Am Osteopath Assoc. 2020 Jul 1;120(7):446-455

Publication

Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of cathepsin D

Kobayashi S, Zhao F, Kobayashi T, Hagiwara M, Kaminaris A, Li C, et al.

Biochem Biophys Res Commun. 2020 Feb 26;523(1):239-245

2019

Publication

Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Kobayashi S, Zhao F, Zhang Z, Kobayashi T, Huang Y, Shi B, et al.

Front Physiol. 2020;11:604069

Publication

Enhanced mTOR complex 1 signaling attenuates diabetic cardiac injury in OVE26 mice

Xu X, Kobayashi S, Timm D, Huang Y, Zhao F, Shou W, et al.

FASEB J. 2019 Nov;33(11):12800-12811

Publication

Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

Catanzaro MP, Weiner A, Kaminaris A, Li C, Cai F, Zhao F, et al.

FASEB J. 2019 Oct;33(10):11096-11108

2016

Publication

Mitochondrial quality control in the diabetic heart

Liang Q, and Kobayashi S

J Mol Cell Cardiol. 2016 Jun;95:57-69

2015

Publication

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al.

Autophagy. 2016;12(1):1-222

Publication

Autophagy and mitophagy in diabetic cardiomyopathy

Kobayashi S, and Liang Q

Biochim Biophys Acta. 2015 Feb;1852(2):252-61

Award

American Heart Association Scientist Development Grant (15SDG25080077)

Lysosomal Dysfunction in the Diabetic Heart. 7/1/2015–6/30/2019, $308,000

AHA Grant

Award

Outstanding Research Award (3rd place)

ACRE/APS Symposium: Hot Topics in CV disease. July 12, 2015, New Orleans, LA

ACRE/APS

2014

Publication

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

Kobayashi S

Biol Pharm Bull. 2015;38(8):1098-103

2013

Publication

Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes

Xu X, Kobayashi S, Chen K, Timm D, Volden P, Huang Y, et al.

J Biol Chem. 2013 Jun 21;288(25):18077-92

2012

Publication

AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice

Chen K, Kobayashi S, Xu X, Viollet B, and Liang Q

PLoS One. 2013;8(3):e59682

Publication

Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury

Kobayashi S, Xu X, Chen K, and Liang Q

Autophagy. 2012 Apr;8(4):577-92

Publication

Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4

Ounzain S, Kobayashi S, Peterson RE, He A, Motterle A, Samani NJ, et al.

Mol Cell Biol. 2012 May;32(10):1830-43

Publication

Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy

Xu X, Chen K, Kobayashi S, Timm D, and Liang Q

J Pharmacol Exp Ther. 2012 Apr;341(1):183-95

2011

Publication

Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms

Chen K, Xu X, Kobayashi S, Timm D, Jepperson T, and Liang Q

J Biol Chem. 2011 Jun 24;286(25):21993-2006

2010

Publication

Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death

Kobayashi S, Volden P, Timm D, Mao K, Xu X, and Liang Q

J Biol Chem. 2010 Jan 1;285(1):793-804

2008

Publication

GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling

Huang Y, Wright CD, Kobayashi S, Healy CL, Elgethun M, Cypher A, et al.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H699-707

Publication

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, et al.

J Mol Cell Cardiol. 2008 Feb;44(2):429-34

Publication

Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats

Chen YF, Kobayashi S, Chen J, Redetzke RA, Said S, Liang Q, et al.

J Mol Cell Cardiol. 2008 Jan;44(1):180-7

Award

Juvenile Diabetes Research Foundation International Advanced Postdoctoral Fellowship (10-2008-457)

Dissecting the Role of Autophagy in Type I Diabetes-Induced Cardiomyopathy. 9/1/2008–8/31/2011, $270,000

JDRF Fellowship

2007

Publication

Chloroplast protein synthesis elongation factor, EF-Tu, reduces thermal aggregation of rubisco activase

Ristic Z, Momcilović I, Fu J, Callegari E, and DeRidder BP

J Plant Physiol. 2007 Dec;164(12):1564-71

Publication

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi S, Mao K, Zheng H, Wang X, Patterson C, O'Connell TD, et al.

J Biol Chem. 2007 Jul 27;282(30):21945-52

Award

New Investigator Travel Award

BCVS Council Symposium, American Heart Association, July 2007, Keystone, CO

AHA BCVS

2006

Publication

Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo

Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, et al.

FASEB J. 2006 Apr;20(6):800-2

Award

The American Heart Association Postdoctoral Fellowship (0625755Z)

Transcription Factor GATA4 Protects from Doxorubicin-induced Cardiotoxicity through Anti-apoptotic Gene Bcl2. 7/1/2006–6/30/2008

AHA Fellowship

2005

Publication

Thyroid hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes

Kuzman JA, Gerdes AM, Kobayashi S, and Liang Q

J Mol Cell Cardiol. 2005 Nov;39(5):841-4

2004

Publication

Chaperone activity of recombinant maize chloroplast protein synthesis elongation factor, EF-Tu

Rao D, Momcilovic I, Kobayashi S, Callegari E, and Ristic Z

Eur J Biochem. 2004 Sep;271(18):3684-92

2002

Publication

Cloning and expression of Bombyx mori silk gland elongation factor 1gamma in Escherichia coli

Kamiie K, Nomura Y, Kobayashi S, Taira H, Kobayashi K, Yamashita T, et al.

Biosci Biotechnol Biochem. 2002 Mar;66(3):558-65

2001

Publication

Detection and characterization of glutathione S-transferase activity in rice EF-1betabeta'gamma and EF-1gamma expressed in Escherichia coli

Kobayashi S, Kidou S, and Ejiri S

Biochem Biophys Res Commun. 2001 Nov 2;288(3):509-14

1998

Publication

Isolation and characterization of a rice cDNA encoding the gamma-subunit of translation elongation factor 1B (eEF1Bgamma)

Kidou S, Tsukamoto S, Kobayashi S, and Ejiri S

FEBS Lett. 1998 Sep 4;434(3):382-6